Poly-L-lactic acid hypodermic filler is a sterile, non-pyrogenic, white or quasi-white injectable micro-sphere made from a biodegradable polymer - poly-L-lactic acid, and injected after re-suspension in a sterile solvent. Poly-L-lactic acid is a biocompatible, biodegradable, synthetic polyhydroxy acid polymer which is composed of poly-L-lactic acid micro-spheres and solvent for injection. After suspension, it is injected into the middle to deep layers of facial dermis. Since L-polylactic acid is a product with a long-lasting degradation , it can shape the face and eliminate wrinkles for as long as 1 to 3 years. Poly-L-lactic acid hypodermic filler is suitable for large-area correction of facial subcutaneous fat and skin collagen loss, and to eliminate facial wrinkles, such as those in foreheads, brows, lateral canthus, cheeks, mouths, necks and so on, making the skin shiny and elastic. It is a good remedy for the defect that botulinum toxin type A can solve dynamic-wrinkle problems only.